NMR is an extremely powerful research tool capable of characterizing at atomic resolution the three-dimensional structure, motional dynamics, folding pathways, and binding kinetics and thermodynamics of biomolecules. The facility provides an ideally suited environment for carrying out investigative research toward challenging biomedical and material problems. Researchers at Rensselaer actively utilize the instrumentation to investigate the structural basis and treatment of diseases such as Alzheimer’s and cancer. Active projects also include basic research in RNA folding, structure-function analysis of protein glycosylation, and the structural basis for protein recognition of natural carbohydrates and for rationally designed carbohydrate-based therapeutics.
- Bruker 800 (18.8 Tesla) and 600 MHz (14.1 Tesla) NMR spectrometer
- Bruker 600 MHz (14.1 Tesla) NMR spectrometer
- Bruker 600 MHz Wide-Bore Solid-State 14T NMR and Multichannel Heteronuclear Microimaging Spectrometer
Each is equipped with 4 RF channels, an ultra-sensitive HCN cryoprobe with a z-axis gradient, and a room temperature HCN probe with triple-axis gradients. Cryoprobes are equipped with cryogenically cooled 1H/13C/15N/2H RF coils and 1H/13C/2H preamplifiers providing for enhanced sensitivity.
In addition, the facility offers both LINUX and Windows based workstations complete with a variety of software packages for data processing and analysis. A sample preparation workspace complete with tabletop, micro, and NMR tube centrifuges, pH meter, and wet bench are also available to facility users. This world class facility is also designed as the future home of an ultra-high field 950-MHz spectrometer, and a 700-MHz wide bore instrument for solid state NMR and microimaging applications. The purchase of a 64 processor LINUX cluster is underway and will be available for applications including structure calculations and high-performance data processing such as non-uniform data sampling and projection reconstruction techniques.
Who can access
Internal users. External users. Training required.
Rates and Fees
Scott McCallum, Ph.D.
Phone: (518) 276-2856